Inconsistent directions of change in case severity across successive SARS-CoV-2 variant waves suggests an unpredictable future

Conclusions The direction of change in disease severity between successively emerging SARS-CoV-2 variants of concern was inconsistent. This heterogeneity in virulence between variants, coupled with independent evolutionary emergence, demonstrates that severity associated with future SARS-CoV-2 variants is inherently unpredictable.

https://www.medrxiv.org/content/10.1101/2022.03.24.22272915v1