L'esposizione al fumo di tabacco durante la gestazione induce danni vascolari che divengono evidenti nella prima età adulta. Ciò potrebbe indicare che se il sistema cardiovascolare viene esposto al fumo di tabacco in utero, i vasi rimangono più vulnerabili al fumo stesso nelle fasi successive della vita. D'altro canto, se la madre fuma ma si è astenuta dal farlo durante la gravidanza, ciò non ha alcuna influenza sullo spessore intima-media della carotide del bambino. Si tratta di dati largamente indipendenti dagli altri fattori di rischio cardiovascolare, il che aumenta la plausibilità dei danni vascolari derivanti dall'esposizione gestazionale al fumo di tabacco.Leggi l'abstract dell'articolo nei commenti.
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l'abstract dell'articolo: http://atvb.ahajournals.org/cgi/content/abstract/28/12/2296?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=smoke&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:2296.)© 2008 American Heart Association, Inc.
Clinical and Population Studies
Parental Smoking and Vascular Damage in Young Adult Offspring: Is Early Life Exposure Critical?
The Atherosclerosis Risk in Young Adults Study Caroline C. Geerts; Michiel L. Bots; Diederick E. Grobbee; Cuno S.P.M. Uiterwaal
From the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
Correspondence to C.S.P.M. Uiterwaal, MD, PhD, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. E-mail c.s.p.m.uiterwaal@umcutrecht.nl
Abstract
Objective— Our purpose was to study the association between familial and particularly fetal tobacco smoke exposure and vascular damage in young adulthood.
Methods and Results— From a cohort of 732 young adults, birth data were collected and in young adulthood ultrasound measurement of common carotid artery intima-media thickness (CIMT) was performed. Data on parental smoking were obtained by standardized questionnaires. Twenty-nine percent of the mothers smoked during pregnancy. Offspring of mothers who smoked had 13.4 µm thicker CIMT (95% CI: 5.5, 21.3; P=0.001) than offspring of mothers who did not smoke in pregnancy. Adjustment for known CIMT risk factors (participant’s age, gender, BMI, pulse pressure, and LDL-cholesterol) yielded no change (9.4 µm, 95% CI: 1.9, 16.3, P=0.01) nor did adjustment for current smoking of parents (10.6 µm, 95% CI: 0.4 to 20.8, P=0.04), for participants’ current smoking and pack-years (11.5 µm, 95% CI: 3.5 to 19.4, P=0.004) or for parental socioeconomic status (SES; 13.0 µm, 95% CI: 5.0, 21.1, P=0.002). Thicker CIMT was associated with exclusive paternal smoking in pregnancy, somewhat stronger with exclusive maternal smoking and strongest with both parents smoking (P linear trend=0.001). Offspring of particularly mothers who smoked an above median number of cigarettes in pregnancy had thicker CIMT than those smoking less than median or no cigarettes (P linear trend <0.0001). Conclusion— Permanent vascular damage is partly attributable to familial tobacco smoke exposure, an association that might be initiated in gestation. In this study the association between tobacco smoke exposure and vascular damage in young adult offspring was investigated. Offspring of mothers who smoked in pregnancy had significantly thicker CIMT than offspring of mothers who did not smoke in pregnancy, indicating that permanent vascular damage attributable to tobacco smoke exposure might be initiated in gestation.
......familial and particularly fetal tobacco smoke exposure and vascular damage in young adulthood...than offspring of mothers who did not smoke in pregnancy. Adjustment for known CIMT...partly attributable to familial tobacco smoke exposure, an association that might be......
CLINICAL AND POPULATION STUDIES: Caroline C. Geerts, Michiel L. Bots, Diederick E. Grobbee, and Cuno S.P.M. Uiterwaal Parental Smoking and Vascular Damage in Young Adult Offspring: Is Early Life Exposure Critical?: The Atherosclerosis Risk in Young Adults Study Arterioscler. Thromb. Vasc. Biol., Dec 2008; 28: 2296 - 2302
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